Georg-Speyer-Haus -
Prof. Dr. Bernd Groner

   
 

> Expertisen

  • Mechanismen der Regulation des Zellwachstums und Interferenz mit Komponenten der Signalübertragung
  • Angewandte Virologie und Gentherapie

> Mitarbeiter

  • Prof. Dr. Winfried Wels (Wachstumsfaktor-Rezeptoren als Zielstrukturen für die Krebs-Immuntherapie)
  • Prof. Dr. Dorothee von Laer (Viren in der molekularen Therapieforschung)
  • Dr. Manuel Grez (Molekulare Ansätze für die Behandlung von angeborenen und erworbenen Gendefekten des Blutsystems)
  • Dr. Ursula Dietrich (Neue antivirale Strategien)
  • Dr. Martin Zörnig (Regulationsmechanismen des programmierten Zelltods (Apoptose)).
  • Dr. Jörn Lausen (Hämatopoietische Transkriptionsfaktoren in Entwicklung und Krankheit
  • Dr. Joachim Koch (Ligandenerkennung und Modulation von NK-Zellrezeptoren)

> Publikationen

  • Groner B, Lucks P, Borghouts-Heinz C: The function of Stat3 in tumor cells and their microenvironment. Seminars in Cell and Developmental Biology 2008; 19:in press.
  • Groner B, Borghouts C: Getting a grip on signalling pathways: a crucial challenge for basic research in oncology. Geburtsh Frauenheilk 2008; 68:244-250.
  • Brill B, Groner B, Boecher N, Shemanko C: A sparing procedure to clear the mouse mammary fat pad of epithelial components for transplantation analysis. Lab Anim 2008; 42:104-110.
  • Borghouts C, Kunz C, Groner B: Peptide aptamer libraries. Comb Chem High Throughput Screen 2008; 11:133-145.
  • Borghouts C, Kunz C, Delis N, Groner B: Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Mol Cancer Res 2008; 6:267-281.
  • Eilton T, Groner B, Barash I: Tumors caused by overexpression and forced activation of Stat5 in mammary epithelial cells of transgenic mice are parity-dependent and developed in aged, postestropausal females. Int J Cancer 2007; 121:1892-1902.
  • Groner B: Introduction: the rationale for the development of targeted drugs in cancer therapy. Recent Results Cancer Res 2007; 172:1-3.
  • Desrivieres S, Prinz T, Kuhn K, Schäfer J, Castro-Palomino-Laria N, Neumann T, Schwartz J, Hamon C and Groner B: Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation. Proteomics 2007; 7:2019-2037.
  • Groner B: The rational for the development of targeted drugs in cancer therapy. Recent Results in Cancer Research: Clinical Relevance of the Targeted Interference with Signal Transduction Events (edited by B. Groner), Springer Verlag Heidelberg 2006;: in press.
  • McGee S, Lanigan F, Gilligan E, Groner B: Mammary gland biology and breast cancer: common molecular mechanisms of mammary gland development and breast cancer progression. EMBO Reports 2006; 7:1084-1088.
  • Kunz C, Borghouts C, Buerger C, Groner B: Peptide aptamers with binding specifity for the intracellular domain of the ErbB2 receptor interfere with heregulin induced signalling and sensitize ErbB2 expressing breast cancer cells to taxol induced cell death. Mol Cancer Res 2006; 4:983-998.
  • Jankiewicz M, Groner B, Desrivieres S: mTOR regulates the growth of mammary epithelial cells through the inhibitor of DNA binding Id1 and their functional differentiation through Id2. Mol Endo 2006; 20:2369-2381.
  • Iavnilovitch E, Eilon T,Groner B, Barash I: Expression of a carboxyl-terminally truncated Stat5, lacking a transactivation domain, in the mammary gland of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion and enhances apoptosis upon involution. Molecular Reproduction and Development 2006; 73:841-849.
  • Desrivieres S, Kunz C, Barash I, Vafaizadeh V, Borghouts C, Groner B: The biological functions of the versatile transcription factors Stat3 and Stat5 and new strategies for their targeted inhibition. J Mammary Gland Biology and Neoplasia 2006; 11:75-87.

 

 

PARTNER

 

DRK Blutspendedienst

Prof. Dr. Erhard Seifried

 

>

Georg-Speyer-Haus

Prof. Dr.
Bernd Groner
 

Max-Planck-Institut
für Hirnforschung

 

Paul-Ehrlich-Institut

Prof. Dr. Johannes Löwer
 

FRANKFURTER INNOVATIONSZENTRUM BIOTECHNOLOGIE (FIZ)

 

GERMAN BREAST GROUP (GBG)

 

KAROLINSKA INSTITUT

 

Klinisches studienzentrum
Rhein-Main (KSRM)

 

Koordinierungszentrum für Klinische Studien (KKS) Heidelberg, Mainz und Marburg

 

Zentrallaboratorium Deutscher Apotheker (ZL)

PROF. SCHUBERT-ZSILAVECZ